Sunday, November 3, 2013

you lean towards despair, at any given opportunity you're there.

Pieces of the puzzle...
*Interictal depression occurs in 25% to 55% of [epilepsy] patients. Further, the suicide rate of persons with epilepsy is more than five times that of controls
*Several reports have indicated that people with epilepsy are at special risk of suicide, particularly those with temporal lobe epilepsy
*Epilepsy and depression may share common pathogenic transmitter mechanisms involving decreased serotonergic, noradrenergic, dopaminergic, and GABAergic activity. Seizure type has been shown to correlate neurologically with depression, which is more common in patients with complex partial seizures, particularly those of temporal lobe origin
*Patients with temporal lobe epilepsy have a higher incidence of affective [mood] and personality disorders, often in comorbidity, than patients with juvenile myoclonic epilepsy and diabetic patients suggesting that these psychiatric disorders are not an adjustment reaction to a chronic disease but rather reflect a limbic dysfunction
*About 4% of the general population has generalized anxiety disorder, a constant state of tension or worry. Again, the number is much higher for people with epilepsy. It's possible that this disorder is caused or made worse by seizures. Anxiety disorders have been associated with the amygdala, a structure in the front part of the temporal lobe. The seizures of temporal lobe epilepsy frequently affect the amygdala and cause it to act in different ways. Anxiety can also be directly related to the possibility of seizures
  *27% of adolescent BPD patients had evidence of brain dysfunction or current epilepsy. They also found history of head trauma, encephalitis, or past seizures in 11%...several episodic or paroxysmal symptoms are common between BPD and temporal lobe epilepsy: impulsivity, transient psychosis, and intermittent experience of depersonalization and derealization
*Hypergraphia is an overwhelming urge to write. It is not itself a disorder, but can be associated with temporal lobe changes in epilepsy...hypergraphia has been observed in 8% of patients with temporal lobe epilepsy
(I laughed aloud when I read this stat)